M

Methylene diphenyl diisocyanate

IUPAC: 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene

C15H10N2O2 Organic Compounds CAS 101-68-8
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Quick Reference
Formula / NotationC15H10N2O2
CAS Number101-68-8
Molecular Weight250.25
Melting Point99 °F (NTP, 1992)
Boiling Point381 to 390 °F at 5 mmHg (NTP, 1992)
Density1.2 at 68 °F (USCG, 1999) - Denser than water; will sink
SolubilityInsoluble (NTP, 1992)
AppearanceDiphenylmethane-4,4-diisocyanate is a light yellow colored solid. It is not soluble in water. It may be toxic by ingestion, inhalation, or skin absorption. If in a solution it may or may not burn d...
Also Known As1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene; 101-68-8; 4,4'-Diphenylmethane diisocyanate; Diphenylmethane diisocyanate; Bis(4-isocyanatophenyl)methane; 4,4'-Methylenebis(phenyl isocyanate); Isonate; Desmodur 44; p,p'-Diphenylmethane diisocyanate; 1,1'-Methylenebis(4-isocyanatobenzene)
CategoryOrganic Compounds

What is Methylene diphenyl diisocyanate?

Diphenylmethane-4,4'-diisocyanate is a diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions. It has a role as an allergen and a hapten. It derives from a hydride of a diphenylmethane.

Formula & Notation

C15H10N2O2

IUPAC Name: 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene

Other Names / Synonyms: 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene; 101-68-8; 4,4'-Diphenylmethane diisocyanate; Diphenylmethane diisocyanate; Bis(4-isocyanatophenyl)methane; 4,4'-Methylenebis(phenyl isocyanate); Isonate; Desmodur 44; p,p'-Diphenylmethane diisocyanate; 1,1'-Methylenebis(4-isocyanatobenzene)

Properties & Characteristics

Appearance: Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. It is not soluble in water. It may be toxic by ingestion, inhalation, or skin absorption. If in a solution it may or may not burn d.... Molecular formula: C15H10N2O2. Molecular weight: 250.25 g/mol. Boiling point: 381 to 390 °F at 5 mmHg (NTP, 1992). Melting point: 99 °F (NTP, 1992). Density: 1.2 at 68 °F (USCG, 1999) - Denser than water; will sink. Solubility: Insoluble (NTP, 1992). Vapor pressure: 5e-06 mmHg at 77 °F (NIOSH, 2024). LogP: 5.4.

Physical Data

PropertyValue
Melting Point99 °F (NTP, 1992)
Boiling Point381 to 390 °F at 5 mmHg (NTP, 1992)
Density1.2 at 68 °F (USCG, 1999) - Denser than water; will sink
Molecular Weight250.25
SolubilityInsoluble (NTP, 1992)
AppearanceDiphenylmethane-4,4-diisocyanate is a light yellow colored solid. It is not soluble in water. It may be toxic by ingestion, inhalation, or skin absorption. If in a solution it may or may not burn d...

Uses & Applications

Used as an industrial feedstock, solvent, pharmaceutical intermediate, flavoring agent, or chemical building block.

Safety Information

Flammable or irritant. Many organic compounds are flammable liquids or vapours. Keep away from ignition sources. Consult SDS for specific hazard data.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Methylene diphenyl diisocyanate
Formula C15H10N2O2
CAS Number 101-68-8
Molecular Weight 250.25
Synonyms 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene; 101-68-8; 4,4'-Diphenylmethane diisocyanate; Diphenylmethane diisocyanate; Bis(4-isocyanatophenyl)methane; 4,4'-Methylenebis(phenyl isocyanate); Isonate; Desmodur 44; p,p'-Diphenylmethane diisocyanate; 1,1'-Methylenebis(4-isocyanatobenzene)

Frequently Asked Questions

Diphenylmethane-4,4'-diisocyanate is a diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions. It has a role as an allergen and a hapten. It derives from a hydride of a diphenylmethane.

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.