H

Hexamethylene diisocyanate

IUPAC: 1,6-diisocyanatohexane

C8H12N2O2 Organic Compounds CAS 822-06-0
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Quick Reference
Formula / NotationC8H12N2O2
CAS Number822-06-0
Molecular Weight168.19
Melting Point-67 °F (NTP, 1992)
Boiling Point491 °F at 760 mmHg (NTP, 1992)
Density1.0528 at 68 °F (NTP, 1992) - Denser than water; will sink
SolubilityReacts with water (NTP, 1992)
AppearanceHexamethylene diisocyanate appears as a colorless crystalline solid. Toxic by ingestion and is strongly irritating to skin and eyes. It is used to make nylon.
Also Known As1,6-diisocyanatohexane; 1,6-Diisocyanatohexane; 822-06-0; HMDI; 1,6-Hexamethylene diisocyanate; Hexane, 1,6-diisocyanato-; Hexane 1,6-diisocyanate; 1,6-Hexylene diisocyanate; Hexamethylene-1,6-diisocyanate; hexamethylenediisocyanate
CategoryOrganic Compounds

What is Hexamethylene diisocyanate?

Hexamethylene diisocyanate is a diisocyanate compound with the two isocyanates linked by a hexane-1,6-diyl group. It has a role as an allergen and a hapten.

Formula & Notation

C8H12N2O2

IUPAC Name: 1,6-diisocyanatohexane

Other Names / Synonyms: 1,6-diisocyanatohexane; 1,6-Diisocyanatohexane; 822-06-0; HMDI; 1,6-Hexamethylene diisocyanate; Hexane, 1,6-diisocyanato-; Hexane 1,6-diisocyanate; 1,6-Hexylene diisocyanate; Hexamethylene-1,6-diisocyanate; hexamethylenediisocyanate

Properties & Characteristics

Appearance: Hexamethylene diisocyanate appears as a colorless crystalline solid. Toxic by ingestion and is strongly irritating to skin and eyes. It is used to make nylon.. Molecular formula: C8H12N2O2. Molecular weight: 168.19 g/mol. Boiling point: 491 °F at 760 mmHg (NTP, 1992). Melting point: -67 °F (NTP, 1992). Density: 1.0528 at 68 °F (NTP, 1992) - Denser than water; will sink. Solubility: Reacts with water (NTP, 1992). Vapor pressure: 0.05 mmHg at 75 °F (NTP, 1992). LogP: 3.2.

Physical Data

PropertyValue
Melting Point-67 °F (NTP, 1992)
Boiling Point491 °F at 760 mmHg (NTP, 1992)
Density1.0528 at 68 °F (NTP, 1992) - Denser than water; will sink
Molecular Weight168.19
SolubilityReacts with water (NTP, 1992)
AppearanceHexamethylene diisocyanate appears as a colorless crystalline solid. Toxic by ingestion and is strongly irritating to skin and eyes. It is used to make nylon.

Uses & Applications

Used as an industrial feedstock, solvent, pharmaceutical intermediate, flavoring agent, or chemical building block.

Safety Information

Flammable or irritant. Many organic compounds are flammable liquids or vapours. Keep away from ignition sources. Consult SDS for specific hazard data.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Hexamethylene diisocyanate
Formula C8H12N2O2
CAS Number 822-06-0
Molecular Weight 168.19
Synonyms 1,6-diisocyanatohexane; 1,6-Diisocyanatohexane; 822-06-0; HMDI; 1,6-Hexamethylene diisocyanate; Hexane, 1,6-diisocyanato-; Hexane 1,6-diisocyanate; 1,6-Hexylene diisocyanate; Hexamethylene-1,6-diisocyanate; hexamethylenediisocyanate

Frequently Asked Questions

Hexamethylene diisocyanate is a diisocyanate compound with the two isocyanates linked by a hexane-1,6-diyl group. It has a role as an allergen and a hapten.

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.