H

Hexafluoroisopropanol

IUPAC: 1,1,1,3,3,3-hexafluoropropan-2-ol

C3H2F6O Solvents CAS 920-66-1
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Quick Reference
Formula / NotationC3H2F6O
CAS Number920-66-1
Molecular Weight168.04
Melting Point25 °F (NTP, 1992)
Boiling Point138 °F at 760 mmHg (NTP, 1992)
Density1.596 at 68 °F (NTP, 1992) - Denser than water; will sink
Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Appearance1,1,1,3,3,3-hexafluoro-2-propanol is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.
Also Known As1,1,1,3,3,3-hexafluoropropan-2-ol; 1,1,1,3,3,3-Hexafluoro-2-propanol; 920-66-1; 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL; HFIP; Hexafluoroisopropyl alcohol; 1,1,1,3,3,3-Hexafluoroisopropanol; Bis(trifluoromethyl)methanol; 2H-Hexafluoroisopropanol; 1,1,1,3,3,3-Hexafluoroisopropyl alcohol
CategorySolvents

What is Hexafluoroisopropanol?

1,1,1,3,3,3-hexafluoropropan-2-ol is an organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane. It has a role as a drug metabolite. It is a secondary alcohol and an organofluorine compound. It is functionally related to a propan-2-ol.

Formula & Notation

C3H2F6O

IUPAC Name: 1,1,1,3,3,3-hexafluoropropan-2-ol

Other Names / Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-ol; 1,1,1,3,3,3-Hexafluoro-2-propanol; 920-66-1; 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL; HFIP; Hexafluoroisopropyl alcohol; 1,1,1,3,3,3-Hexafluoroisopropanol; Bis(trifluoromethyl)methanol; 2H-Hexafluoroisopropanol; 1,1,1,3,3,3-Hexafluoroisopropyl alcohol

Properties & Characteristics

Appearance: 1,1,1,3,3,3-hexafluoro-2-propanol is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.. Molecular formula: C3H2F6O. Molecular weight: 168.04 g/mol. Boiling point: 138 °F at 760 mmHg (NTP, 1992). Melting point: 25 °F (NTP, 1992). Density: 1.596 at 68 °F (NTP, 1992) - Denser than water; will sink. Solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992). Vapor pressure: 158 mmHg at 72 °F ; 556 mmHg at 124 °F; 1468 mmHg at 167 °F (NTP, 1992). LogP: 1.7.

Physical Data

PropertyValue
Melting Point25 °F (NTP, 1992)
Boiling Point138 °F at 760 mmHg (NTP, 1992)
Density1.596 at 68 °F (NTP, 1992) - Denser than water; will sink
Molecular Weight168.04
Solubilitygreater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Appearance1,1,1,3,3,3-hexafluoro-2-propanol is a clear colorless oily liquid with an aromatic odor. (NTP, 1992) Combustible, may cause burns to skin, eyes and mucous membranes.

Uses & Applications

Used as a reaction solvent in organic synthesis, extraction solvent, cleaning agent, or in pharmaceutical manufacture.

Safety Information

Flammable solvent. Keep away from heat, sparks, and open flame. Use in well-ventilated area or fume hood. Consult SDS before use.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Hexafluoroisopropanol
Formula C3H2F6O
CAS Number 920-66-1
Molecular Weight 168.04
Category Solvents
Synonyms 1,1,1,3,3,3-hexafluoropropan-2-ol; 1,1,1,3,3,3-Hexafluoro-2-propanol; 920-66-1; 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL; HFIP; Hexafluoroisopropyl alcohol; 1,1,1,3,3,3-Hexafluoroisopropanol; Bis(trifluoromethyl)methanol; 2H-Hexafluoroisopropanol; 1,1,1,3,3,3-Hexafluoroisopropyl alcohol

Frequently Asked Questions

1,1,1,3,3,3-hexafluoropropan-2-ol is an organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane. It has a role as a drug metabolite. It is a secondary alcohol and an organofluorine compound. It is functionally related to a propan-2-ol.

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.