T

Triglyme

IUPAC: 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane

C8H18O4 Solvents CAS 112-49-2
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Quick Reference
Formula / NotationC8H18O4
CAS Number112-49-2
Molecular Weight178.23
Melting Point-49 °F (NTP, 1992)
Boiling Point421 °F at 760 mmHg (NTP, 1992)
Density0.99 at 68 °F (NTP, 1992) - Less dense than water; will float
Solubilitygreater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
AppearanceTriethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. (NTP, 1992)
Also Known As1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane; 2,5,8,11-TETRAOXADODECANE; 112-49-2; Triethylene glycol dimethyl ether; 1,2-Bis(2-methoxyethoxy)ethane; Glyme 4; Ansul ether 161; Glyme-3; TEGDIME; TEGDME
CategorySolvents

What is Triglyme?

Triglyme is a polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms. It has a role as a solvent.

Formula & Notation

C8H18O4

IUPAC Name: 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane

Other Names / Synonyms: 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane; 2,5,8,11-TETRAOXADODECANE; 112-49-2; Triethylene glycol dimethyl ether; 1,2-Bis(2-methoxyethoxy)ethane; Glyme 4; Ansul ether 161; Glyme-3; TEGDIME; TEGDME

Properties & Characteristics

Appearance: Triethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. (NTP, 1992). Molecular formula: C8H18O4. Molecular weight: 178.23 g/mol. Boiling point: 421 °F at 760 mmHg (NTP, 1992). Melting point: -49 °F (NTP, 1992). Density: 0.99 at 68 °F (NTP, 1992) - Less dense than water; will float. Solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992). Vapor pressure: 0.9 mmHg at 68 °F (NTP, 1992). LogP: -0.5.

Physical Data

PropertyValue
Melting Point-49 °F (NTP, 1992)
Boiling Point421 °F at 760 mmHg (NTP, 1992)
Density0.99 at 68 °F (NTP, 1992) - Less dense than water; will float
Molecular Weight178.23
Solubilitygreater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
AppearanceTriethylene glycol dimethyl ether is a clear colorless liquid with a mild ethereal odor. (NTP, 1992)

Uses & Applications

Used as a reaction solvent in organic synthesis, extraction solvent, cleaning agent, or in pharmaceutical manufacture.

Safety Information

Flammable solvent. Keep away from heat, sparks, and open flame. Use in well-ventilated area or fume hood. Consult SDS before use.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Triglyme
Formula C8H18O4
CAS Number 112-49-2
Molecular Weight 178.23
Category Solvents
Synonyms 1-methoxy-2-[2-(2-methoxyethoxy)ethoxy]ethane; 2,5,8,11-TETRAOXADODECANE; 112-49-2; Triethylene glycol dimethyl ether; 1,2-Bis(2-methoxyethoxy)ethane; Glyme 4; Ansul ether 161; Glyme-3; TEGDIME; TEGDME

Frequently Asked Questions

Triglyme is a polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms. It has a role as a solvent.

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.