Dexamethasone
IUPAC: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
| Formula / Notation | C22H29FO5 |
|---|---|
| CAS Number | 50-02-2 |
| Molecular Weight | 392.5 |
| Melting Point | 504 to 507 °F (NTP, 1992) |
| Solubility | less than 1 mg/mL at 77 °F (NTP, 1992) |
| Appearance | Dexamethazone is an odorless white to off-white crystalline powder with a slightly bitter taste. (NTP, 1992) |
| Also Known As | (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 50-02-2; Decadron; Aeroseb-Dex; Cortisumman; Calonat; Decaderm; Dexacortal; Dexacortin; Prednisolone F |
| Category | Organic Compounds |
What is Dexamethasone?
Dexamethasone is a fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids. It has a role as an anti-inflammatory drug, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an adrenergic agent, an antiemetic and an environmental contaminant. It is a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a hydride of a pregnane.
Formula & Notation
IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Other Names / Synonyms: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one; 50-02-2; Decadron; Aeroseb-Dex; Cortisumman; Calonat; Decaderm; Dexacortal; Dexacortin; Prednisolone F
Properties & Characteristics
Physical Data
| Property | Value |
|---|---|
| Melting Point | 504 to 507 °F (NTP, 1992) |
| Molecular Weight | 392.5 |
| Solubility | less than 1 mg/mL at 77 °F (NTP, 1992) |
| Appearance | Dexamethazone is an odorless white to off-white crystalline powder with a slightly bitter taste. (NTP, 1992) |
Uses & Applications
Safety Information
Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.
Key Facts
Frequently Asked Questions
Dexamethasone is a fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids. It has a role as an anti-inflammatory drug, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an adrenergic agent, an antiemetic and an environmental contaminant. It is a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a hydride of a pregnane.
Used as an industrial feedstock, solvent, pharmaceutical intermediate, flavoring agent, or chemical building block.
Flammable or irritant. Many organic compounds are flammable liquids or vapours. Keep away from ignition sources. Consult SDS for specific hazard data.
The formula or notation for Dexamethasone is: C22H29FO5