Hydrophilic
| Formula / Notation | ΔG_solvation < 0 |
|---|---|
| Also Known As | Water-loving, water-soluble (related), polar, water-miscible |
What is Hydrophilic?
Describes molecules or groups that are attracted to water and readily dissolve in or absorb water. Hydrophilic substances typically have polar bonds or charged groups. The term means "water-loving." Hydrophilic molecules can form hydrogen bonds with water.
Formula & Notation
Other Names / Synonyms: Water-loving, water-soluble (related), polar, water-miscible
Properties & Characteristics
Uses & Applications
Safety Information
Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.
Key Facts
Frequently Asked Questions
Describes molecules or groups that are attracted to water and readily dissolve in or absorb water. Hydrophilic substances typically have polar bonds or charged groups. The term means "water-loving." Hydrophilic molecules can form hydrogen bonds with water.
Hydrophilic properties determine biological availability: hydrophilic drugs are water-soluble but may have limited membrane permeability; balance with hydrophobicity (Lipinski's Rule of Five) is needed for oral bioavailability. Hydrophilic polymers (PEG, polyvinyl alcohol) are used as coatings in dr…
Hydrophilic chemicals generally absorb well into aqueous environments (bloodstream, body fluids). This can mean rapid systemic distribution of toxic hydrophilic substances. Highly hydrophilic ionic compounds (heavy metal salts, HCN) are readily absorbed from aqueous exposures.
The formula or notation for Hydrophilic is: ΔG_solvation < 0