Dermal Toxicity
| Formula / Notation | flux = Kp × C_skin |
|---|---|
| Also Known As | Skin absorption toxicity, percutaneous toxicity, contact toxicity, topical toxicity |
What is Dermal Toxicity?
The capacity of a substance to cause harmful effects when it contacts or penetrates the skin. Dermal toxicity assessments evaluate skin irritation, sensitization, and systemic toxicity from skin absorption. It is an important factor in occupational safety and product safety evaluation.
Formula & Notation
Other Names / Synonyms: Skin absorption toxicity, percutaneous toxicity, contact toxicity, topical toxicity
Properties & Characteristics
Uses & Applications
Safety Information
Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.
Key Facts
Frequently Asked Questions
The capacity of a substance to cause harmful effects when it contacts or penetrates the skin. Dermal toxicity assessments evaluate skin irritation, sensitization, and systemic toxicity from skin absorption. It is an important factor in occupational safety and product safety evaluation.
Dermal toxicity data is used to set occupational exposure limits (dermal OELs), to design skin-protective PPE, in transdermal drug delivery (nicotine patches, hormone patches exploit controlled percutaneous absorption), and in cosmetic and pesticide safety assessment.
For chemicals with significant dermal absorption (e.g., organophosphate pesticides, dimethyl sulfoxide DMSO, hydrofluoric acid), gloves alone may be insufficient — full protective clothing is required. Dermal LD₅₀ values guide hazard classification. Skin exposure must be minimised for Category 1 der…
The formula or notation for Dermal Toxicity is: flux = Kp × C_skin