D

Differential Scanning Calorimetry (DSC)

dH/dt = C_p × (dT/dt)
Quick Reference
Formula / NotationdH/dt = C_p × (dT/dt)
Also Known AsDSC, differential scanning calorimeter, thermal analysis (DSC method)

What is Differential Scanning Calorimetry (DSC)?

A thermal analysis technique that measures the heat flow into or out of a sample as a function of temperature or time. DSC is used to study phase transitions, melting points, glass transitions, and reaction enthalpies in materials science and pharmaceuticals.

Formula & Notation

dH/dt = C_p × (dT/dt)

Other Names / Synonyms: DSC, differential scanning calorimeter, thermal analysis (DSC method)

Properties & Characteristics

Differential Scanning Calorimetry (DSC) is a thermoanalytical technique that measures the heat flow difference between a sample and an inert reference as both are subjected to the same controlled temperature programme. Endothermic events (melting, glass transition, denaturation) show upward deflections; exothermic events (crystallisation, curing, decomposition) show downward deflections in standard DSC plots. It measures T_m, T_g, ΔH of transitions, and C_p.

Uses & Applications

DSC is used for pharmaceutical polymorph characterisation and purity determination, polymer glass transition and melting behaviour, food analysis (fat crystallisation, starch gelatinisation), biomolecule stability (protein Tm), energetic material safety screening, and quality control of raw materials.

Safety Information

DSC of energetic materials (explosives, propellants, peroxides) can reveal decomposition onset temperatures. Samples must be loaded carefully; high-pressure DSC pans are used for reactive samples. Thermal runaway detection by DSC is a key tool in chemical process safety.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Differential Scanning Calorimetry (DSC)
Formula dH/dt = C_p × (dT/dt)
Synonyms DSC, differential scanning calorimeter, thermal analysis (DSC method)

Frequently Asked Questions

A thermal analysis technique that measures the heat flow into or out of a sample as a function of temperature or time. DSC is used to study phase transitions, melting points, glass transitions, and reaction enthalpies in materials science and pharmaceuticals.

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