P

Penicillin G

IUPAC: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

C16H18N2O4S Organic Compounds CAS 61-33-6
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Quick Reference
Formula / NotationC16H18N2O4S
CAS Number61-33-6
Molecular Weight334.4
Melting Point214-217 °C
DensityMP 106-110 °C (WITH DECOMPOSITION); DENSITY 1.255-1.256; AQ SOLN ARE DEXTROROTATORY; SOLUBILITIES @
SolubilitySlightly soluble (210 mg/L)
AppearanceSolid
Also Known As(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Benzylpenicillin; 61-33-6; Benzylpenicillinic acid; Benzyl penicillin; Liquacillin; Free penicillin II; Specilline G; Dropcillin; Free penicillin G
CategoryOrganic Compounds

What is Penicillin G?

Benzylpenicillin is a penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group. It has a role as an antibacterial drug, an epitope and a drug allergen. It is a penicillin and a penicillin allergen. It is a conjugate acid of a benzylpenicillin(1-).

Formula & Notation

C16H18N2O4S

IUPAC Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Other Names / Synonyms: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Benzylpenicillin; 61-33-6; Benzylpenicillinic acid; Benzyl penicillin; Liquacillin; Free penicillin II; Specilline G; Dropcillin; Free penicillin G

Properties & Characteristics

Appearance: Solid. Molecular formula: C16H18N2O4S. Molecular weight: 334.4 g/mol. Melting point: 214-217 °C. Density: MP 106-110 °C (WITH DECOMPOSITION); DENSITY 1.255-1.256; AQ SOLN ARE DEXTROROTATORY; SOLUBILITIES @ 28 °C: 6.8 MG/ML IN WATER, GREATER THAN 20 MG/ML IN METHANOL, 0.075 MG/ML IN BENZENE, 1.05 IN T.... Solubility: Slightly soluble (210 mg/L). LogP: 1.8.

Physical Data

PropertyValue
Melting Point214-217 °C
DensityMP 106-110 °C (WITH DECOMPOSITION); DENSITY 1.255-1.256; AQ SOLN ARE DEXTROROTATORY; SOLUBILITIES @
Molecular Weight334.4
SolubilitySlightly soluble (210 mg/L)
AppearanceSolid

Uses & Applications

Used as an industrial feedstock, solvent, pharmaceutical intermediate, flavoring agent, or chemical building block.

Safety Information

Flammable or irritant. Many organic compounds are flammable liquids or vapours. Keep away from ignition sources. Consult SDS for specific hazard data.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Penicillin G
Formula C16H18N2O4S
CAS Number 61-33-6
Molecular Weight 334.4
Synonyms (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Benzylpenicillin; 61-33-6; Benzylpenicillinic acid; Benzyl penicillin; Liquacillin; Free penicillin II; Specilline G; Dropcillin; Free penicillin G

Frequently Asked Questions

Benzylpenicillin is a penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group. It has a role as an antibacterial drug, an epitope and a drug allergen. It is a penicillin and a penicillin allergen. It is a conjugate acid of a benzylpenicillin(1-).

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.