Inhibition
| Formula / Notation | Ki = [I]×Km / ([S](Vm/v − 1)) |
|---|---|
| Also Known As | Enzyme inhibition, reaction inhibition, chemical inhibitor, competitive inhibition |
What is Inhibition?
The reduction of a chemical reaction rate or enzymatic activity by an inhibitor molecule. Competitive inhibition involves molecules binding to the active site; non-competitive inhibition occurs elsewhere. Inhibition is important in drug design and metabolic regulation.
Formula & Notation
Other Names / Synonyms: Enzyme inhibition, reaction inhibition, chemical inhibitor, competitive inhibition
Properties & Characteristics
Uses & Applications
Safety Information
Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.
Key Facts
Frequently Asked Questions
The reduction of a chemical reaction rate or enzymatic activity by an inhibitor molecule. Competitive inhibition involves molecules binding to the active site; non-competitive inhibition occurs elsewhere. Inhibition is important in drug design and metabolic regulation.
Inhibition is exploited in: pharmaceutical drugs (enzyme inhibitors as drugs — statins inhibit HMG-CoA reductase; ACE inhibitors for hypertension; NSAIDs inhibit COX enzymes), food preservation (antioxidants inhibit radical oxidation), corrosion inhibitors in pipelines, and reaction safety (inhibito…
Toxic enzyme inhibitors include: organophosphate nerve agents and pesticides (irreversible AChE inhibitors), cyanide (cytochrome c oxidase inhibitor), carbon monoxide (haemoglobin and cytochrome c oxidase inhibitor). Inhibitor removal from stored monomers before polymerisation must be done carefully…
The formula or notation for Inhibition is: Ki = [I]×Km / ([S](Vm/v − 1))