T

Trimethylsilyl chloride

IUPAC: chloro(trimethyl)silane

C3H9ClSi Laboratory Reagents CAS 75-77-4
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Quick Reference
Formula / NotationC3H9ClSi
CAS Number75-77-4
Molecular Weight108.64
Melting Point-72 °F (EPA, 1998)
Boiling Point135 °F at 760 mmHg (EPA, 1998)
Density0.854 at 77 °F (EPA, 1998) - Less dense than water; will float
SolubilityDecomposes (NTP, 1992)
AppearanceTrimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135 °F, Flash point -18 °F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are h...
Also Known Aschloro(trimethyl)silane; Chlorotrimethylsilane; 75-77-4; TRIMETHYLCHLOROSILANE; Silane, chlorotrimethyl-; Trimethyl chlorosilane; Monochlorotrimethylsilicon; Silane, trimethylchloro-; Silicane, chlorotrimethyl-; Silylium, trimethyl-, chloride
CategoryLaboratory Reagents

What is Trimethylsilyl chloride?

Chlorotrimethylsilane is a silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

Formula & Notation

C3H9ClSi

IUPAC Name: chloro(trimethyl)silane

Other Names / Synonyms: chloro(trimethyl)silane; Chlorotrimethylsilane; 75-77-4; TRIMETHYLCHLOROSILANE; Silane, chlorotrimethyl-; Trimethyl chlorosilane; Monochlorotrimethylsilicon; Silane, trimethylchloro-; Silicane, chlorotrimethyl-; Silylium, trimethyl-, chloride

Properties & Characteristics

Appearance: Trimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135 °F, Flash point -18 °F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are h.... Molecular formula: C3H9ClSi. Molecular weight: 108.64 g/mol. Boiling point: 135 °F at 760 mmHg (EPA, 1998). Melting point: -72 °F (EPA, 1998). Density: 0.854 at 77 °F (EPA, 1998) - Less dense than water; will float. Solubility: Decomposes (NTP, 1992). Vapor pressure: 608 mmHg at 68 °F ; 40 mmHg at 11.5 °F; 100 mmHg at 42.8 °F (NTP, 1992).

Physical Data

PropertyValue
Melting Point-72 °F (EPA, 1998)
Boiling Point135 °F at 760 mmHg (EPA, 1998)
Density0.854 at 77 °F (EPA, 1998) - Less dense than water; will float
Molecular Weight108.64
SolubilityDecomposes (NTP, 1992)
AppearanceTrimethylchlorosilane appears as a colorless fuming liquid with a pungent odor. Boiling point 135 °F, Flash point -18 °F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are h...

Uses & Applications

Used as a synthetic reagent for transformations including oxidation, reduction, coupling, or functional group manipulation.

Safety Information

Hazardous reagent. May be toxic, corrosive, flammable, or reactive. Use in fume hood with full PPE. Consult SDS before use.

Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.

Key Facts

Term Trimethylsilyl chloride
Formula C3H9ClSi
CAS Number 75-77-4
Molecular Weight 108.64
Synonyms chloro(trimethyl)silane; Chlorotrimethylsilane; 75-77-4; TRIMETHYLCHLOROSILANE; Silane, chlorotrimethyl-; Trimethyl chlorosilane; Monochlorotrimethylsilicon; Silane, trimethylchloro-; Silicane, chlorotrimethyl-; Silylium, trimethyl-, chloride

Frequently Asked Questions

Chlorotrimethylsilane is a silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

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Editorial standards: Chemical data is sourced from peer-reviewed literature, CAS Registry, NIST WebBook, and PubChem. Safety information reflects guidance from OSHA, ECHA, and IAEA. For educational purposes only — always consult official SDS documentation and qualified professionals before handling chemicals.