Labile
| Also Known As | Kinetically labile complex, labile coordination compound, fast-exchange complex |
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What is Labile?
In coordination chemistry, a term describing a complex in which ligand substitution reactions occur rapidly. Labile complexes are kinetically unstable but may be thermodynamically stable. In contrast, inert complexes undergo slow ligand substitution.
Properties & Characteristics
Uses & Applications
Safety Information
Always consult the SDS/MSDS before handling any chemical. This information is for educational purposes only.
Key Facts
Frequently Asked Questions
In coordination chemistry, a term describing a complex in which ligand substitution reactions occur rapidly. Labile complexes are kinetically unstable but may be thermodynamically stable. In contrast, inert complexes undergo slow ligand substitution.
Lability determines the rate of metal-ligand substitution reactions important in: synthesis of new coordination complexes (template synthesis requires labile exchange), biological function of metalloenzymes (carbonic anhydrase Zn²⁺ is labile, allowing rapid CO₂ hydration), and in medicine (Pt²⁺ comp…
Labile metal complexes in biological systems exchange ligands rapidly, which can displace essential biometals from enzyme active sites. Toxic metal ions (Cd²⁺, Hg²⁺) form labile complexes with sulfhydryl groups in proteins, explaining their toxicity.